ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Xuezhikang Capsule on the serum levels of inflammatory factors such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in patients with nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia, and to explore whether it has anti-inflammatory effect.</p><p><b>METHODS</b>A total of 84 patients were randomly assigned to two groups with stratified block randomization, the treatment group (42 cases) and the control group (42 cases). They were treated with Xuezhikang Capsule and polyene phosphatidylcholine capsule for twenty-four weeks, respectively. The changes in serum TNF-alpha and IL-6 were measured by enzyme linked immunosorbent assay before treatment and at the 12th and 24th week.</p><p><b>RESULTS</b>Compared with those before treatment, the serum levels of TNF-alpha and IL-6 significantly decreased in both groups after treatment (P<0.01). There was no significant change between the two groups for the treatments at different time points (P>0.05) and between the two groups for treatments at the same time points (P>0.05).</p><p><b>CONCLUSION</b>Xuezhikang Capsule can inhibit the serum inflammatory factor in patients with NAFLD and hyperlipidemia.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Administration, Oral , Anti-Inflammatory Agents, Non-Steroidal , Pharmacology , Capsules , Drugs, Chinese Herbal , Pharmacology , Fatty Liver , Blood , Drug Therapy , Hyperlipidemias , Blood , Drug Therapy , Hypolipidemic Agents , Pharmacology , Interleukin-6 , Blood , Lipids , Blood , Liver , Liver Function Tests , Treatment Outcome , Tumor Necrosis Factor-alpha , BloodABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Xuesaitong soft capsule (XST) on liver fibrosis criteria in patients with post-hepatitis fibrosis.</p><p><b>METHODS</b>Sixty-four patients with such fibrosis were randomly divided into the treated group and control group. They were treated with XST and Dahuang Zhechong pill (NFDA1) for 3 months respectively. Their liver fibrosis criteria were examined before and after treatment.</p><p><b>RESULTS</b>The levels of serum procollagen III, hyaluronic acid, collagen IV, laminin in the two groups were significantly lower (P < 0.01) than those before treatment. The differences between the two groups were insignificant (P > 0.05).</p><p><b>CONCLUSION</b>XST could recover liver dysfunction and had anti-liver fibrosis function.</p>